Tubal ligation in relation to menopausal symptoms and breast cancer risk.

ABSTRACT:

Background

Local inflammation after tubal ligation may affect ovarian function and breast cancer risk.

Methods

We analysed tubal ligation, menopausal characteristics, and breast cancer risk in the Sister Study cohort (N=50,884 women).

Results

Tubal ligation was associated with hot flashes (hazard ratio (HR) 1.09; 95% confidence interval (CI): 1.06-1.12) but not menopausal age (HR 0.99; 95% CI: 0.96-1.02). Tubal ligation did not have an impact on breast cancer overall (HR 0.95; 95% CI: 0.85-1.06), but had a suggested inverse relation with oestrogen receptor+/progesterone receptor+ invasive tumours (HR 0.84; 95% CI: 0.70-1.01), possibly because of subsequent hysterectomy/bilateral oophorectomy.

Conclusion

Tubal ligation does not influence overall breast cancer ri

SUBMITTER: Nichols HB 

PROVIDER: S-EPMC3778289 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature