Synthesis of mucin-type O-glycan probes as aminopropyl glycosides.

ABSTRACT: The chemical synthesis of a series of mucin-type oligosaccharide fragments 1-7 containing an α-linked aminopropyl spacer ready for glycoarray attachment is reported. A highly convergent and stereoselective strategy that employs two different orthogonal protected galactosamine building blocks was used to access all of the targets. A tandem deprotection sequence, that did not require chromatography-based purification between steps, was employed to globally unmask all protecting groups and all final targets were isolated in good to excellent yields.

SUBMITTER: Benito-Alifonso D 

PROVIDER: S-EPMC3778329 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature