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New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei.


ABSTRACT: Chemical analysis of the organic extract of Theonella swinhoei yielded two new tridecadepsipeptides of the theonellapeptolide family, namely sulfinyltheonellapeptolide, characterized by a methylsulfinylacetyl group at the N-terminus, and theonellapeptolide If, the first member of this class of compounds to show four valine residues. The structures of the compounds, isolated along with the known theonellapeptolide Id, were determined by extensive 2D NMR and MS/MS analyses followed by application of Marfey's method. The isolated peptides exhibited moderate antiproliferative activity against HepG2 cells, a hepatic carcinoma cell line.

SUBMITTER: Sinisi A 

PROVIDER: S-EPMC3778368 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei.

Sinisi Annamaria A   Calcinai Barbara B   Cerrano Carlo C   Dien Henny A HA   Zampella Angela A   D'Amore Claudio C   Renga Barbara B   Fiorucci Stefano S   Taglialatela-Scafati Orazio O  

Beilstein journal of organic chemistry 20130813


Chemical analysis of the organic extract of Theonella swinhoei yielded two new tridecadepsipeptides of the theonellapeptolide family, namely sulfinyltheonellapeptolide, characterized by a methylsulfinylacetyl group at the N-terminus, and theonellapeptolide If, the first member of this class of compounds to show four valine residues. The structures of the compounds, isolated along with the known theonellapeptolide Id, were determined by extensive 2D NMR and MS/MS analyses followed by application  ...[more]

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