The rapid generation of isothiocyanates in flow.

ABSTRACT: Isothiocyanates are versatile starting materials for a wide range of chemical reactions. However, their high nucleophilic susceptibility means they are best prepared and used immediately. We report here on a flow platform for the fast and efficient formation of isothiocyanates by the direct conversion of easily prepared chloroximes. To expedite this chemistry a flow insert cartridge containing two immobilised reagents is used to affect the chemical transformation which typically eliminates the requirements for any conventional work-up or purification of the reaction stream.

SUBMITTER: Baumann M 

PROVIDER: S-EPMC3778409 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature