Genome-wide mapping of gene-microbiota interactions in susceptibility to autoimmune skin blistering.

ABSTRACT: Susceptibility to chronic inflammatory diseases is determined by immunogenetic and environmental risk factors. Resident microbial communities often differ between healthy and diseased states, but whether these differences are of primary aetiological importance or secondary to the altered inflammatory environment remains largely unknown. Here we provide evidence for host gene-microbiota interactions contributing to disease risk in a mouse model of epidermolysis bullosa acquisita, an autoantibody-induced inflammatory skin disease. Using an advanced intercross, we identify genetic loci contributing to skin microbiota variability, susceptibility to skin blistering and their overlap. Furthermore, by treating bacterial species abundances as covariates with disease we reveal a novel disease locus

SUBMITTER: Srinivas G 

PROVIDER: S-EPMC3778513 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature