In vitro antioxidant and H(+), K(+)-ATPase inhibition activities of Acalypha wilkesiana foliage extract.

ABSTRACT:

Aims

The aim of this study was to evaluate the antioxidant activty and anti-acid property of Acalypha wilkesiana foliage extract.

Materials and methods

Hot and cold aqueous extracts were prepared from healthy leaves of A. wilkesiana. Free radical scavenging activity and H(+), K(+)-ATPase inhibition activities of aqueous foliage extracts was screened by in vitro models.

Statistical analysis used

All experiments were performed in triplicate and results are expressed as mean ± SEM.

Results

A. wilkesiana hot aqueous extract (AWHE) showed significant antioxidants and free radical scavenging activity. Further, AWHE has shown a potent H(+), K(+)-ATPase inhibitory activity (IC50: 51.5 ± 0.28 μg/ml) when compare to standard proton pump inhibitor omeprazole (56.2 ± 0.64

SUBMITTER: Prakash Gupta RK 

PROVIDER: S-EPMC3778591 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature