Non-invasive metabolomic analysis using a commercial NIR instrument for embryo selection.

ABSTRACT:

Context

Metabolomics was introduced in human in vitro fertilization (IVF) for noninvasive identification of viable embryos with the highest developmental competence.

Aims

To determine whether embryo selection using a commercial version of metabolomic analysis leads to increased implantation rates (IRs) with fetal cardiac activity (FCA) compared with morphology evaluation alone.

Setting and design

Randomized controlled trial from April to December 2010 at a private IVF unit. The study was terminated prematurely due to the market withdrawal of the instrument.

Materials and methods

IVF patients ≥18 and ≤43 years with ≥4 × 2PN were randomly allocated to metabolomic analysis combined with embryo morphology (ViaMetrics-E; metabolomics + morphology group) or embryo mo

SUBMITTER: Sfontouris IA 

PROVIDER: S-EPMC3778603 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature