Lung clearance index as an outcome measure for clinical trials in young children with cystic fibrosis. A pilot study using inhaled hypertonic saline.

ABSTRACT:

Rationale

Lung clearance index (LCI), measured by multiple breath washout (MBW), is a noninvasive measure of ventilation inhomogeneity that holds promise as an objective physiologic endpoint for clinical trials in infants and preschool children with cystic fibrosis (CF).

Objectives

To study the feasibility of using LCI to assess treatment effect outcomes in CF trials of infants and preschoolers.

Methods

The Infant Study of Inhaled Saline trial was a multicenter, randomized, controlled trial of hypertonic (7%) versus isotonic (0.9%) saline inhaled twice daily for 48 weeks in children with CF under 6 years of age. LCI measurements were performed in a single-center pilot substudy at baseline and 48 weeks using a respiratory mass spectrometer and sulfur hexafluoride as th

SUBMITTER: Subbarao P 

PROVIDER: S-EPMC3778738 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature