Lifetime adiposity and risk of pancreatic cancer in the NIH-AARP Diet and Health Study cohort.

ABSTRACT:

Background

The association of excess body weight across a lifetime with pancreatic cancer has not been examined extensively.

Objective

We determined the association for body mass index (BMI) at different ages and adiposity duration and gain with incident pancreatic adenocarcinoma in the NIH-AARP Diet and Health Study cohort.

Design

Participants aged 50-71 y completed questionnaires at baseline (1995-1996) and 6 months later that queried height and weight history. We calculated HRs and 95% CIs by using Cox proportional hazards models adjusted for age, smoking, sex, and intakes of energy and total fat.

Results

Over an average follow-up of 10.5 y, 1206 and 2122 pancreatic cancer cases were identified in the subcohort who completed the second questionnaire (n = 273

SUBMITTER: Stolzenberg-Solomon RZ 

PROVIDER: S-EPMC3778860 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature