An investigation of a genomewide supported psychosis variant in ZNF804A and white matter integrity in the human brain.

ABSTRACT: ZNF804A, a genomewide supported susceptibility gene for schizophrenia and bipolar disorder, has been associated with task-independent functional connectivity between the left and right dorsolateral prefrontal cortices. Several lines of evidence have converged on the hypothesis that this effect may be mediated by structural connectivity. We tested this hypothesis using diffusion tensor magnetic resonance imaging in three samples: one German sample of 50 healthy individuals, one Scottish sample of 83 healthy individuals and one Scottish sample of 84 unaffected relatives of bipolar patients. Voxel-based analysis and tract-based spatial statistics did not detect any fractional anisotropy (FA) differences between minor allele carriers and individuals homozygous for the major allele at rs1344706

SUBMITTER: Sprooten E 

PROVIDER: S-EPMC3778890 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature