CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice.

ABSTRACT:

Aims

To determine the role of CD13 as an adhesion molecule in trafficking of inflammatory cells to the site of injury in vivo and its function in wound healing following myocardial infarction induced by permanent coronary artery occlusion.

Methods and results

Seven days post-permanent ligation, hearts from CD13 knockout (CD13(KO)) mice showed significant reductions in cardiac function, suggesting impaired healing in the absence of CD13. Mechanistically, CD13(KO) infarcts showed an increase in small, endothelial-lined luminal structures, but no increase in perfusion, arguing against an angiogenic defect in the absence of CD13. Cardiac myocytes of CD13(KO) mice showed normal basal contractile function, eliminating myocyte dysfunction as a mechanism of adverse remodelling. Conv

SUBMITTER: Pereira FE 

PROVIDER: S-EPMC3778957 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature