Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia.

ABSTRACT: Pre-eclampsia is a serious complication of pregnancy that can affect both maternal and fetal outcomes. Early-onset pre-eclampsia (EOPET) is a severe form of pre-eclampsia that is associated with altered physiological characteristics and gene expression in the placenta. DNA methylation is a relatively stable epigenetic modification to DNA that can reflect gene expression, and can provide insight into the mechanisms underlying such expression changes. This case-control study focused on DNA methylation and gene expression of whole chorionic villi samples from 20 EOPET placentas and 20 gestational age-matched controls from pre-term births. DNA methylation was also assessed in placentas affected by late-onset pre-eclampsia (LOPET) and normotensive intrauterine growth restriction (nIUGR). The Il

SUBMITTER: Blair JD 

PROVIDER: S-EPMC3779005 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature