Maternal asthma and microRNA regulation of soluble HLA-G in the airway.

ABSTRACT:

Background

We previously reported an interaction between maternal asthma and the child's HLA-G genotype on the child's subsequent risk for asthma. The implicated single nucleotide polymorphism at +3142 disrupted a target site for the microRNA (miR)-152 family. We hypothesized that the interaction effect might be mediated by these miRs.

Objective

The objective of this study was to test this hypothesis in adults with asthma who are a subset of the same subjects who participated in our earlier family-based studies.

Methods

We measured soluble HLA-G (sHLA-G) concentrations in bronchoalveolar lavage fluid (n = 36) and plasma (n = 57) from adult asthmatic subjects with and without a mother with asthma, and HLA-G and miR-152 family (miR-148a, miR-148b, and miR-152) transcrip

SUBMITTER: Nicodemus-Johnson J 

PROVIDER: S-EPMC3779062 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature