Pax6 is required for normal cell-cycle exit and the differentiation kinetics of retinal progenitor cells.

ABSTRACT: The coupling between cell-cycle exit and onset of differentiation is a common feature throughout the developing nervous system, but the mechanisms that link these processes are mostly unknown. Although the transcription factor Pax6 has been implicated in both proliferation and differentiation of multiple regions within the central nervous system (CNS), its contribution to the transition between these successive states remains elusive. To gain insight into the role of Pax6 during the transition from proliferating progenitors to differentiating precursors, we investigated cell-cycle and transcriptomic changes occurring in Pax6 (-) retinal progenitor cells (RPCs). Our analyses revealed a unique cell-cycle phenotype of the Pax6-deficient RPCs, which included a reduced number of cells in the S

SUBMITTER: Farhy C 

PROVIDER: S-EPMC3779171 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature