Morphologic assessment for glaucoma in the Multicenter Uveitis Steroid Treatment (MUST) trial.

ABSTRACT:

Purpose

To compare Reading Center (RC) cup-to-disc ratio (CDR) assessment from stereoscopic photographs with clinician estimation in a uveitis clinical trial.

Methods

Clinical estimation of CDR was performed by ophthalmologists via dilated biomicroscopy. Photographic evaluation was performed at an independent RC by masked, certified evaluators. Quality control was performed by repeat grading of 77 randomly selected images.

Results

Among 479 eyes with uveitis, 353 eyes had clinical and photographic grades for CDR. Agreement between clinical and RC grading was fair, with exact agreement of 29%. Agreement within 0.1 and 0.2 CDR was 70 and 93%, respectively (weighted κ = .34). Intergrader reproducibility at the RC was better (weighted κ = .59, ICC 0.74).

Conclusion

SUBMITTER: Gangaputra SS 

PROVIDER: S-EPMC3779435 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature