Synthesis of spirocyclic indolines by interruption of the Bischler-Napieralski reaction.

ABSTRACT: The development of a versatile method for the synthesis of spirocyclic pyrrolidinoindolines is discussed. Treatment of N-acyltryptamines with trifluoromethanesulfonic anhydride-2-chloropyridine reagent combination affords highly persistent spiroindoleninium ions that are subject to intra- and intermolecular addition at C2 by nucleophiles.

SUBMITTER: Medley JW 

PROVIDER: S-EPMC3779471 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature