T2 texture index of cartilage can predict early symptomatic OA progression: data from the osteoarthritis initiative.

ABSTRACT:

Objective

There is an interest in using Magnetic Resonance Imaging (MRI) to identify pre-radiographic changes in osteoarthritis (OA) and features that indicate risk for disease progression. The purpose of this study is to identify image features derived from MRI T2 maps that can accurately predict onset of OA symptoms in subjects at risk for incident knee OA.

Methods

Patients were selected from the Osteoarthritis Initiative (OAI) control cohort and incidence cohort and stratified based on the change in total Western Ontario and McMaster Universities Arthritis (WOMAC) score from baseline to 3-year follow-up (80 non-OA progression and 88 symptomatic OA progression patients). For each patient, a series of image texture features were measured from the baseline cartilage T2 map.

SUBMITTER: Urish KL 

PROVIDER: S-EPMC3779506 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature