Zinc enhances long-term potentiation through P2X receptor modulation in the hippocampal CA1 region.

ABSTRACT: Zn²(+) is an essential ion that is stored in and co-released from glutamatergic synapses and it modulates neurotransmitter receptors involved in long-term potentiation (LTP). However, the mechanism(s) underlying Zn²(+) -induced modulation of LTP remain(s) unclear. As the purinergic P2X receptors are relevant targets for Zn²(+) action, we have studied their role in LTP modulation by Zn²(+) in the CA1 region of rat hippocampal slices. Induction of LTP in the presence of Zn²(+) revealed a biphasic effect - 5-50 μm enhanced LTP induction, whereas 100-300 μm Zn²(+) inhibited LTP. The involvement of a purinergic mechanism is supported by the fact that application of the P2X receptor antagonists 2',3'-O-(2,4,6-trinitrophenyl) ATP (TNP-ATP) and periodate-oxidized ATP fully abolished the facilitato

SUBMITTER: Lorca RA 

PROVIDER: S-EPMC3779873 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature