Suicide-related events in young people following prescription of SSRIs and other antidepressants: a self-controlled case series analysis.

ABSTRACT:

Objectives

We aimed to examine the temporal association between selective serotonin reuptake inhibitors (SSRI) and tricyclic antidepressant (TCA) prescriptions and suicide-related events in children and adolescents.

Design

Self-controlled case series.

Setting

Electronic health records were used from 479 general practices in The Health Improvement Network (THIN) UK primary care database from 1995 to 2009.

Participants

81 young people aged 10-18 years with a record of completed suicide, 1496 who attempted suicide, 1178 with suicidal ideation and 2361 with intentional self-harm.

Main outcome measures

Incidence Rate Ratios (IRRs) for completed and attempted suicide, suicidal ideation and intentional self-harm.

Results

For non-fatal suicide-related beh

SUBMITTER: Wijlaars LP 

PROVIDER: S-EPMC3780295 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature