Oestrogen receptor polymorphisms are an associated risk factor for mild cognitive impairment and Alzheimer disease in women APOE {varepsilon}4 carriers: a case-control study.

ABSTRACT:

Objectives

Examine the role of single nucleotide polymorphisms (SNPs) in the oestrogen receptor (ER) genes: rs9340799, rs2234693, rs2228480 (in the ESR1 gene) and rs4986938 (in the ESR2 gene) as a risk factor for amnesic mild cognitive impairment (MCIa) and Alzheimer's disease (AD) and its possible association with the apolipoprotein E (APOE) gene.

Design

We have investigated the independent and combined association of different alleles of the oestrogen receptor genes and APOE*ε4 allele with cognitive impairment using a case-control design.

Setting

Participants were prospectively recruited from the neurology departments of several Basque Country hospitals.

Participants

This study comprised 816 Caucasian participants who were aged 50 years and older: 204 MCIa, 3

SUBMITTER: Fernandez-Martinez M 

PROVIDER: S-EPMC3780298 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature