Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.

ABSTRACT: We found that CNS-directed expression of interferon-γ (IFN-γ) resulted in basal ganglia calcification, reminiscent of human idiopathic basal ganglia calcification (IBGC), and nigrostriatal degeneration. Our results indicate that IFN-γ mediates age-progressive nigrostriatal degeneration in the absence of exogenous stressors. Further study of this model may provide insight into selective nigrostriatal degeneration in human IBGC and other Parkinson syndromes.

SUBMITTER: Chakrabarty P 

PROVIDER: S-EPMC3780582 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature