Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury.

ABSTRACT:

Background

Clinical trial and epidemiological data support that the cardiovascular effects of estrogen are complex, including a mixture of both potentially beneficial and harmful effects. In animal models, estrogen protects females from vascular injury and inhibits atherosclerosis. These effects are mediated by estrogen receptors (ERs), which, when bound to estrogen, can bind to DNA to directly regulate transcription. ERs can also activate several cellular kinases by inducing a rapid nonnuclear signaling cascade. However, the biological significance of this rapid signaling pathway has been unclear.

Methods and results

In the present study, we develop a novel transgenic mouse in which rapid signaling is blocked by overexpression of a peptide that prevents ERs from interacting

SUBMITTER: Bernelot Moens SJ 

PROVIDER: S-EPMC3780602 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature