Using arterial spin labeling perfusion MRI to explore how midazolam produces anterograde amnesia.

ABSTRACT: While our previous work suggests that the midazolam-induced memory impairment results from the inhibition of new association formation, little is known about the neural correlates underlying these effects beyond the effects of GABA agonists on the brain. We used arterial spin-labeling perfusion MRI to measure cerebral blood flow changes associated with the effects of midazolam on ability to learn arbitrary word-pairs. Using a double-blind, within-subject cross-over design, subjects studied word-pairs for a later cued-recall test while they were scanned. Lists of different word-pairs were studied both before and after an injection of either saline or midazolam. As expected, recall was severely impaired under midazolam. The contrast of MRI signal before and after midazolam administration rev

SUBMITTER: Liang P 

PROVIDER: S-EPMC3780778 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature