Metabolomic markers reveal novel pathways of ageing and early development in human populations.

ABSTRACT:

Background

Human ageing is a complex, multifactorial process and early developmental factors affect health outcomes in old age.

Methods

Metabolomic profiling on fasting blood was carried out in 6055 individuals from the UK. Stepwise regression was performed to identify a panel of independent metabolites which could be used as a surrogate for age. We also investigated the association with birthweight overall and within identical discordant twins and with genome-wide methylation levels.

Results

We identified a panel of 22 metabolites which combined are strongly correlated with age (R(2) = 59%) and with age-related clinical traits independently of age. One particular metabolite, C-glycosyl tryptophan (C-glyTrp), correlated strongly with age (beta = 0.03, SE = 0.001, P =

SUBMITTER: Menni C 

PROVIDER: S-EPMC3781000 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature