Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials.

ABSTRACT:

Background

Huperzine A is a Chinese herb extract used for Alzheimer's disease. We conducted this review to evaluate the beneficial and harmful effect of Huperzine A for treatment of Alzheimer's disease.

Methods

We searched for randomized clinical trials (RCTs) of Huperzine A for Alzheimer's disease in PubMed, Cochrane Library, and four major Chinese electronic databases from their inception to June 2013. We performed meta-analyses using RevMan 5.1 software. (Protocol ID: CRD42012003249).

Results

20 RCTs including 1823 participants were included. The methodological quality of most included trials had a high risk of bias. Compared with placebo, Huperzine A showed a significant beneficial effect on the improvement of cognitive function as measured by Mini-Mental State Ex

SUBMITTER: Yang G 

PROVIDER: S-EPMC3781107 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature