The association of skin intrinsic fluorescence with type 1 diabetes complications in the DCCT/EDIC study.

ABSTRACT:

Objective

To determine whether skin intrinsic fluorescence (SIF) is associated with long-term complications of type 1 diabetes (T1D) and, if so, whether it is independent of chronic glycemic exposure and previous intensive therapy.

Research design and methods

We studied 1,185 (92%) of 1,289 active Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) participants from 2010 to 2011. SIF was determined using a fluorescence spectrometer and related cross-sectionally to recently determined measures of retinopathy (stereo fundus photography), cardiac autonomic neuropathy (CAN; R-R interval), confirmed clinical neuropathy, nephropathy (albumin excretion rate [AER]), and coronary artery calcification (CAC).

Results

Ov

SUBMITTER: Orchard TJ 

PROVIDER: S-EPMC3781515 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature