Expression profiles of the nuclear receptors and their transcriptional coregulators during differentiation of neural stem cells.

ABSTRACT: Neural stem cells (NSCs) are pluripotent precursors with the ability to proliferate and differentiate into 3 neural cell lineages, neurons, astrocytes and oligodendrocytes. Elucidation of the mechanisms underlying these biologic processes is essential for understanding both physiologic and pathologic neural development and regeneration after injury. Nuclear hormone receptors (NRs) and their transcriptional coregulators also play crucial roles in neural development, functions and fate. To identify key NRs and their transcriptional regulators in NSC differentiation, we examined mRNA expression of 49 NRs and many of their coregulators during differentiation (0-5 days) of mouse embryonic NSCs induced by withdrawal of fibroblast growth factor-2 (FGF2). 37 out of 49 NRs were expressed in NSCs be

SUBMITTER: Androutsellis-Theotokis A 

PROVIDER: S-EPMC3781591 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature