A local regulatory network around three NAC transcription factors in stress responses and senescence in Arabidopsis leaves.

ABSTRACT: A model is presented describing the gene regulatory network surrounding three similar NAC transcription factors that have roles in Arabidopsis leaf senescence and stress responses. ANAC019, ANAC055 and ANAC072 belong to the same clade of NAC domain genes and have overlapping expression patterns. A combination of promoter DNA/protein interactions identified using yeast 1-hybrid analysis and modelling using gene expression time course data has been applied to predict the regulatory network upstream of these genes. Similarities and divergence in regulation during a variety of stress responses are predicted by different combinations of upstream transcription factors binding and also by the modelling. Mutant analysis with potential upstream genes was used to test and confirm some of the predict

SUBMITTER: Hickman R 

PROVIDER: S-EPMC3781708 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature