An association between peptidoglycan synthesis and organization of the Streptococcus pyogenes ExPortal.

ABSTRACT:

Unlabelled

The ExPortal of Streptococcus pyogenes is a focal microdomain of the cytoplasmic membrane that clusters the translocons of the general secretory pathway with accessory factors to facilitate the maturation of secreted polypeptides. While it is known that the ExPortal is enriched in anionic lipids, the mechanisms that organize the ExPortal are poorly understood. In the present study, we examined the role of the cell wall in organizing and maintaining the ExPortal. Removal of the cell wall resulted in a loss of ExPortal focal integrity accompanied by the circumferential redistribution of ExPortal lipid and protein components. A similar loss occurred upon treatment with gallidermin, a nonpermeabilizing lantibiotic that targets the lipid II precursor of peptidoglycan synthesi

SUBMITTER: Vega LA 

PROVIDER: S-EPMC3781834 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature