Basal levels of (p)ppGpp in Enterococcus faecalis: the magic beyond the stringent response.

ABSTRACT:

Unlabelled

The stringent response (SR), mediated by the alarmone (p)ppGpp, is a conserved bacterial adaptation system controlling broad metabolic alterations necessary for survival under adverse conditions. In Enterococcus faecalis, production of (p)ppGpp is controlled by the bifunctional protein RSH (for "Rel SpoT homologue"; also known as RelA) and by the monofunctional synthetase RelQ. Previous characterization of E. faecalis strains lacking rsh, relQ, or both revealed that RSH is responsible for activation of the SR and that alterations in (p)ppGpp production negatively impact bacterial stress survival and virulence. Despite its well-characterized role as the effector of the SR, the significance of (p)ppGpp during balanced growth remains poorly understood. Microarrays of E. fae

SUBMITTER: Gaca AO 

PROVIDER: S-EPMC3781836 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature