Upregulation of human β-defensin-3 and cathelicidin LL-37 in Kaposi's sarcoma.

ABSTRACT:

Background

Kaposi's sarcoma (KS) is a rare neoplasm of lymphatic endothelial cells. Human herpes virus 8 (HHV-8) is considered to be a necessary, but not sufficient causal agent of KS and additional cofactors remain unknown. In this study we evaluated the expression of human β defensin (HBD)-3 and LL-37 in cutaneous lesions of KS in comparison to the healthy skin of normal subjects.

Methods

We performed a quantitative immunohistochemical study of HBD-3 and LL-37 on skin lesions from 18 patients having KS, and on healthy skin from 12 normal controls.

Results

HBD-3 and LL-37 were significantly upregulated in epidermal and dermal specimens of all KS patients in comparison to normal skin of healthy controls. The immunostaining score of dermal HBD-3 was significantly highe

SUBMITTER: Fathy H 

PROVIDER: S-EPMC3782342 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature