No evidence for association of the MDM2-309 T/G promoter polymorphism with prostate cancer outcomes.

ABSTRACT:

Objectives

Mouse double-minute 2 (MDM2) SNP309 polymorphism (T>G) has been correlated with an increased risk of cancer in multiple tumor types. MDM2 overexpression has shown to be weakly associated with distant tumor metastases, and down-regulation of MDM2 via antisense oligonucleotides in vitro has resulted in the radiosensitization of prostate cancer cell lines. Based on these results, we decided to evaluate the role of MDM2 SNP309 in the context of histopathologic parameters and clinical outcomes in prostate cancer tumors.

Materials and methods

The population consisted of 212 consecutive prostate cancer patients who underwent radical prostatectomy between 1997 and 1999 at Vanderbilt University Medical Center. Two hundred eight of the samples were successfully genotyped fo

SUBMITTER: Jaboin JJ 

PROVIDER: S-EPMC3782416 | biostudies-literature | 2011 May-Jun

REPOSITORIES: biostudies-literature