Proteomics analysis of human obesity reveals the epigenetic factor HDAC4 as a potential target for obesity.

ABSTRACT: Sedentary lifestyle and excessive energy intake are prominent contributors to obesity; a major risk factors for the development of insulin resistance, type 2 diabetes and cardiovascular diseases. Elucidating the molecular mechanisms underlying these chronic conditions is of relevant importance as it might lead to the identification of novel anti-obesity targets. The purpose of the current study is to investigate differentially expressed proteins between lean and obese subjects through a shot-gun quantitative proteomics approach using peripheral blood mononuclear cells (PBMCs) extracts as well as potential modulation of those proteins by physical exercise. Using this approach, a total of 47 proteins showed at least 1.5 fold change between lean and obese subjects. In obese, the proteomic pro

SUBMITTER: Abu-Farha M 

PROVIDER: S-EPMC3782461 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature