Characterization of the gut-associated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis.

ABSTRACT:

Introduction

Inflammatory complications following ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) are common and thought to arise through mechanisms similar to de novo onset inflammatory bowel disease. The aim of this study was to determine whether specific organisms in the tissue-associated microbiota are associated with inflammatory pouch complications.

Methods

Patients having previously undergone IPAA were recruited from Mount Sinai Hospital. Clinical and demographic information were collected and a pouchoscopy with biopsy of both the pouch and afferent limb was performed. Patients were classified based on post-surgical phenotype into four outcome groups: familial adenomatous polyposis controls (FAP), no pouchitis, pouchitis, and Crohn's disease-like (CDL)

SUBMITTER: Tyler AD 

PROVIDER: S-EPMC3782502 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature