Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants.

ABSTRACT:

Context

Previous functional neuroimaging studies have identified a network of brain regions that process aversive stimuli, including anger. A polymorphism near the cyclic adenosine monophosphate response element binding protein gene (CREB1) has recently been associated with greater self-reported effort at anger control as well as risk for antidepressant treatment-emergent suicidality in men with major depressive disorder, but its functional effects have not been studied.

Objective

To determine whether this genetic variant is associated with altered brain processing of and behavioral avoidance responses to angry facial expressions.

Design and participants

A total of 28 white participants (mean age, 29.2 years; 13 women) were screened using the Structured Clinical Inter

SUBMITTER: Perlis RH 

PROVIDER: S-EPMC3782742 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature