Effectiveness of extended-duration transdermal nicotine therapy: a randomized trial.

ABSTRACT:

Background

Tobacco dependence is a chronic, relapsing condition that may require extended treatment.

Objective

To assess whether extended-duration transdermal nicotine therapy increases abstinence from tobacco more than standard-duration therapy in adult smokers.

Design

Parallel randomized, placebo-controlled trial from September 2004 to February 2008. Participants and all research personnel except the database manager were blinded to randomization. (ClinicalTrials.gov registration number: NCT00364156)

Setting

Academic center.

Participants

568 adult smokers.

Intervention

In an unstratified small block-randomization scheme, participants were randomly assigned to standard therapy (Nicoderm CQ [GlaxoSmithKline, Research Triangle Park, North Carolina]

SUBMITTER: Schnoll RA 

PROVIDER: S-EPMC3782858 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature