Widespread evidence of cooperative DNA binding by transcription factors in Drosophila development.

ABSTRACT: Regulation of eukaryotic gene transcription is often combinatorial in nature, with multiple transcription factors (TFs) regulating common target genes, often through direct or indirect mutual interactions. Many individual examples of cooperative binding by directly interacting TFs have been identified, but it remains unclear how pervasive this mechanism is during animal development. Cooperative TF binding should be manifest in genomic sequences as biased arrangements of TF-binding sites. Here, we explore the extent and diversity of such arrangements related to gene regulation during Drosophila embryogenesis. We used the DNA-binding specificities of 322 TFs along with chromatin accessibility information to identify enriched spacing and orientation patterns of TF-binding site pairs. We devel

SUBMITTER: Kazemian M 

PROVIDER: S-EPMC3783179 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature