Loss of the histidine kinase DhkD results in mobile mounds during development of Dictyostelium discoideum.

ABSTRACT:

Background

Histidine kinases are receptors for sensing cellular and environmental signals, and in response to the appropriate cue they initiate phosphorelays that regulate the activity of response regulators. The Dictyostelium discoideum genome encodes 15 histidine kinases that function to regulate several processes during the multicellular developmental program, including the slug to culmination transition, osmoregulation, and spore differentiation. While there are many histidine kinases, there is only a single response regulator, RegA. Not surprisingly given the ubiquitous involvement of cAMP in numerous processes of development in Dictyostelium, RegA is a cAMP phosphodiesterase that is activated upon receiving phosphates through a phosphorelay. Hence, all of the histidine kinase

SUBMITTER: Singleton CK 

PROVIDER: S-EPMC3783435 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature