What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?

ABSTRACT: Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by a large number of physical and chemical stimuli, which involves them with sensory cell physiology. The vanilloid TRP subfamily (TRPV) named after the vanilloid receptor 1 (TRPV1) consists of six members, and at least four of them (TRPV1-TRPV4) have been related to thermal sensation. One of the least characterized members of the TRP subfamily is TRPV2. Although initially characterized as a noxious heat sensor, TRPV2 now seems to have little to do with temperature sensing but a much more complex physiological profile. Here we review the available information and research progress on the structure, physiology and pharmacology of TRPV2 i

SUBMITTER: Peralvarez-Marin A 

PROVIDER: S-EPMC3783526 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature