Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury.

ABSTRACT:

Objective

Preclinical and clinical studies have suggested that therapeutic hypothermia, while decreasing neurologic injury, may also lead to drug toxicity that may limit its benefit. Cooling decreases cytochrome P450 (CYP)-mediated drug metabolism, and limited clinical data suggest that drug levels are elevated. Fosphenytoin is metabolized by cytochrome P450 2C, has a narrow therapeutic range, and is a commonly used antiepileptic medication. The objective of this study was to evaluate the impact of therapeutic hypothermia on phenytoin levels and pharmacokinetics in children with severe traumatic brain injury.

Design

Pharmacokinetic analysis of subjects participating in a multicenter randomized phase III study of therapeutic hypothermia for severe traumatic brain injury.

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SUBMITTER: Empey PE 

PROVIDER: S-EPMC3783553 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature