Personality and risk of Alzheimer's disease: new data and meta-analysis.

ABSTRACT:

Background

We examine whether broad factors and specific facets of personality are associated with increased risk of incident Alzheimer's disease (AD) in a long-run longitudinal study and a meta-analysis of published studies.

Methods

Participants (n = 1671) were monitored for up to 22 years from a baseline personality assessment. The meta-analysis pooled results from up to five prospective studies (n = 5054).

Results

Individuals with scores in the top quartile of neuroticism (hazard ratio = 3.1; 95% confidence interval = 1.6-6.0) or the lowest quartile of conscientiousness (hazard ratio = 3.3; 95% confidence interval = 1.4-7.4) had a threefold increased risk of incident AD. Among the components of these traits, self-discipline and depression had the strongest associat

SUBMITTER: Terracciano A 

PROVIDER: S-EPMC3783589 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature