Sense-antisense gene pairs: sequence, transcription, and structure are not conserved between human and mouse.

ABSTRACT: Previous efforts to characterize conservation between the human and mouse genomes focused largely on sequence comparisons. These studies are inherently limited because they don't account for gene structure differences, which may exist despite genomic sequence conservation. Recent high-throughput transcriptome studies have revealed widespread and extensive overlaps between genes, and transcripts, encoded on both strands of the genomic sequence. This overlapping gene organization, which produces sense-antisense (SAS) gene pairs, is capable of effecting regulatory cascades through established mechanisms. We present an evolutionary conservation assessment of SAS pairs, on three levels: genomic, transcriptomic, and structural. From a genome-wide dataset of human SAS pairs, we first identified o

SUBMITTER: Wood EJ 

PROVIDER: S-EPMC3783845 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature