Sustained-release fampridine (4-aminopyridine) in multiple sclerosis: efficacy and impact on motor function.

ABSTRACT:

Objective

The aim of this study was to determine the efficacy of sustained-release fampridine (4-aminopyridine) in veterans with multiple sclerosis (MS) with limited ambulatory ability, and its impact on motor function in an outpatient setting.

Design

Retrospective.

Setting

Tertiary referral center [Veterans Affairs (VA) Medical Center].

Participants

Veterans; 20 MS patients were prescribed dalfampridine (10 mg twice daily) due to their difficulty with walking based on patient and caregiver report and clinician impression of change in the ability to ambulate based on prior 10-meter (10M) and 2-minute walk tests (2MWTs).

Intervention

Not applicable.

Main outcome measures

The primary outcome measures were mean changes in walking speed (10M walk test

SUBMITTER: Rabadi MH 

PROVIDER: S-EPMC3784065 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature