Obesity, diabetes, and survival outcomes in a large cohort of early-stage breast cancer patients.

ABSTRACT:

Background

To determine the relationship between obesity, diabetes, and survival in a large cohort of breast cancer patients receiving modern chemotherapy and endocrine therapy.

Patients and methods

We identified 6342 patients with stage I-III breast cancer treated between 1996 and 2005. Patients were evaluated according to body mass index (BMI) category and diabetes status.

Results

In a multivariate model adjusted for body mass index, diabetes, medical comorbidities, patient- and tumor-related variables, and adjuvant therapies, relative to the normal weight, hazard ratios (HRs) for recurrence-free survival (RFS), overall survival (OS), and breast cancer-specific survival (BCSS) for the overweight were 1.18 [95% confidence interval (CI) 1.02-1.36], 1.20 (95% CI 1.00-1

SUBMITTER: Jiralerspong S 

PROVIDER: S-EPMC3784334 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature