Exploring the spatial and temporal organization of a cell's proteome.

ABSTRACT: To increase our current understanding of cellular processes, such as cell signaling and division, knowledge is needed about the spatial and temporal organization of the proteome at different organizational levels. These levels cover a wide range of length and time scales: from the atomic structures of macromolecules for inferring their molecular function, to the quantitative description of their abundance, and spatial distribution in the cell. Emerging new experimental technologies are greatly increasing the availability of such spatial information on the molecular organization in living cells. This review addresses three fields that have significantly contributed to our understanding of the proteome's spatial and temporal organization: first, methods for the structure determination of ind

SUBMITTER: Beck M 

PROVIDER: S-EPMC3784337 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature