Association between Helicobacter pylori infection and pancreatic cancer development: a meta-analysis.

ABSTRACT:

Background

Pancreatic cancer is one of the most troublesome malignancies with dismal prognosis. H. pylori has been recognized as a type I carcinogen. Several studies have evaluated the association between H. pylori infection and pancreatic cancer development, however, the conclusions are inconsistent.

Methods

Literature search was carried out in PubMed, EMBASE, Cochrane Library and CNKI databases to identify eligible researches. We performed overall meta-analysis of all studies included and subgroup analysis based on regional distribution. Quality of the studies (assessed by Newcastle-Ottawa quality assessment scale for case-control studies) and CagA+ strains of H. pylori were taken into consideration, and we conducted additional analyses including high-quality researches an

SUBMITTER: Xiao M 

PROVIDER: S-EPMC3784458 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature