Cell- and subunit-specific mechanisms of CNG channel ciliary trafficking and localization in C. elegans.

ABSTRACT: Primary cilia are ubiquitous sensory organelles that concentrate transmembrane signaling proteins essential for sensing environmental cues. Mislocalization of crucial ciliary signaling proteins, such as the tetrameric cyclic nucleotide-gated (CNG) channels, can lead to cellular dysfunction and disease. Although several cis- and trans-acting factors required for ciliary protein trafficking and localization have been identified, whether these mechanisms act in a protein- and cell-specific manner is largely unknown. Here, we show that CNG channel subunits can be localized to discrete ciliary compartments in individual sensory neurons in C. elegans, suggesting that channel composition is heterogeneous across the cilium. We demonstrate that ciliary localization of CNG channel subunits is interd

SUBMITTER: Wojtyniak M 

PROVIDER: S-EPMC3784820 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature