MUC5AC and inflammatory mediators associated with respiratory outcomes in the British 1946 birth cohort.

ABSTRACT:

Background and objective

Dysregulation of respiratory mucins, MUC5AC in particular, has been implicated in respiratory disease and MUC5AC expression is up-regulated in response to environmental challenges and inflammatory mediators. The aim of this study was to examine the effect of genetic variation on susceptibility to common respiratory conditions.

Methods

The association of MUC5AC and the closely linked genes MUC2 and MUC5B with respiratory outcomes was tested in the MRC National Survey of Health and Development, a longitudinal birth cohort of men and women born in 1946. Also examined were the functional variants of the genes encoding inflammatory mediators, IL13, IL1B, IL1RN, TNFA and ERBB1, for which there is a likely influence on MUC5AC expression and were explored po

SUBMITTER: Johnson L 

PROVIDER: S-EPMC3784974 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature