Familial aggregation of left ventricular geometry and association with parental heart failure: the Framingham Heart Study.

ABSTRACT:

Background

Data regarding the familial aggregation of left ventricular (LV) geometry and its relations to parental heart failure (HF) are limited.

Methods and results

We evaluated concordance of LV geometry within 1093 nuclear families in 5758 participants of the original (parents) (n=2351) and offspring (n=3407) cohorts of the Framingham Heart Study undergoing routine echocardiography in mid- to late adulthood. LV geometry was categorized based on cohort- and sex-specific 80th percentile cutoffs of LV mass and relative wall thickness (RWT) into normal (both <80th percentile), concentric remodeling (LV mass <80th percentile; RWT >80th percentile), concentric hypertrophy (both >80th percentile), and eccentric hypertrophy (LV mass >80th percentile; RWT <80th percentile). Withi

SUBMITTER: Lam CS 

PROVIDER: S-EPMC3785074 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature