A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation.

ABSTRACT: This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC3785133 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature